Abraham A. Palmer Lab Research Data Collection
Owning Institution: UC San Diego, Research Data Curation Program
About this CollectionWe are interested in the relationship between genes and behavior. By identifying genes that influence behavior we hope to obtain fundamental mechanistic insights into the molecular basis of both health and disease. Our research uses mice, rats, and humans in pursuit of these goals.
A major focus of our work is on refining methods for genome-wide association studies (GWAS) in model organisms. Past efforts to identify chromosomal regions that are associated with behavioral and other traits have used intercrosses (F2s), recombinant inbred (RI) strains, and related populations to identify quantitative trait loci (QTLs). While quite successful, these approaches have been unable to map QTLs to intervals that are small enough to permit gene identification. This is because the parental chromosomes have not been sufficiently recombined, so haplotypes are extremely large. To address this problem, we have focused our efforts on populations with greater numbers of recombinations.
In this collection, we deposit large datasets that were produced and analyzed in Palmer Lab using Carworth Farms White (CFW) mice, advanced intercross line (AIL) mice, rats, and zebrafish. These datasets include behavioral data and physiological data, as well as links to the DNA, RNA, and omics data deposited to other repositories.
This collection excludes work performed in N/NIH heterogeneous stock (HS) outbred rats; for this work, see cgord.org and the UC San Diego Library C-GORD collection (The Center for GWAS in Outbred Rats Database (C-GORD) at https://doi.org/10.6075/J0MS3SZ5. View this collection on the contributor's website.
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