Under copyright Constraint(s) on Use: This work is protected by the U.S. Copyright Law (Title 17, U.S.C.). Use of this work beyond that allowed by "fair use" or any license applied to this work requires written permission of the copyright holder(s). Responsibility for obtaining permissions and any use and distribution of this work rests exclusively with the user and not the UC San Diego Library. Inquiries can be made to the UC San Diego Library program having custody of the work. Use: This work is available from the UC San Diego Library. This digital copy of the work is intended to support research, teaching, and private study.
Rights Holder and Contact
UC Regents
Description
Portion of a proximal convoluted tubule from a rat kidney with experimental hemoglobinuria. A mass of dense hemoglobin completely fills the tubule lumen and outlines the microvilli of the brush border. The penetration of hemoglobin along the intercellular spaces is blocked at the level of the tight junctions (also known as zonula occludens) and does not appear in the adherens junctions (also known as zonula adherens) or in the distended intercellular spaces below the level of the shallow tight junctions. Hemoglobin also has been internalized via large clathrin coated vesicles and appears in endosomes and lysosomes.First demonstration that the tight junction acts as a barrier preventing passage of proteins along the intercellular spaces by forming a seal between adjacent cells. First demonstration of the shallow nature of the tight junctions between epithelial cells in the proximal tubule. Identical labeled image available as CIL# 7623. Image published as Figure 24 in Farquhar and Palade, 1963. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Farquhar, Marilyn G.; Palade, George E. (2021). CIL:7622, Rattus rattus, epithelial cell, rat kidney proximal tubule epithelial cell. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0RR1WZJ
If you're wondering about permissions and what you can do with this item, a good starting point is the "rights information" on this page. See our terms of use for more tips.
Share your story
Has Calisphere helped you advance your research, complete a project, or find something meaningful? We'd love to hear about it; please send us a message.
