Research based PAM50 Signature from the Women's Healthy Eating and Living (WHEL) Study
Creator
Pierce, John P
Contributor
Ellis, Matthew J. Mardis, Elaine R. Parker, Barbara A. Flatt, Shirley W. Pittman, Emily Messer, Karen Natarajan, Loki Davies, Sherri R. Marinac, Catherine R. Nelson, Sandahl H. Vickery, Tammi L.
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Rights Holder and Contact
UC Regents
Description
Intrinsic molecular subtypes defined by mRNA expression of 50 genes (PAM50) are prognostic in hormone-receptor positive postmenopausal breast cancer. This study used archived 1253 FFPE breast samples with high quality reads to test the long-term prognostic value of the PAM50 signature in pre- and post-menopausal breast cancer, and to investigate if the PAM50 model could be improved by addition of other mRNAs implicated in oncogenesis. It was concluded that PAM50 intrinsic subtypes were independently prognostic for long-term breast cancer survival, irrespective of menopausal status. National Cancer Institute, National Institutes of Health, Awards No. R01CA166293 (KM, LN, MP, JP, BP, SF, ERM, ME, SD, TV), P30CA023100 (KM, LN, MP, EP) and F32CA220859 (CRM) Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Pu, Minya; Messer, Karen; Davies, Sherri R.; Vickery, Tammi L.; Pittman, Emily; Parker, Barbara A.; Ellis, Matthew J.; Flatt, Shirley W.; Marinac, Catherine R.; Nelson, Sandahl H.; Mardis, Elaine R.; Pierce, John P.; Natarajan, Loki (2023). Research based PAM50 Signature from the Women's Healthy Eating and Living (WHEL) Study. UC San Diego Library Digital Collections. https://doi.org/10.6075/J0TB172H
Type
dataset
Identifier
ark:/20775/bb5164388z
Language
English
Subject
Prognostic modeling Gene signatures Hypoxia PAM50 subtypes Breast cancer Long-term survival
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