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The data in this collection comes from the publication titled “Genetic characterization of outbred Sprague Dawley rats and utility for genome-wide association studies”, authored by Gileta et al. The majority of the collection is dedicated to the supplementary information (figures, tables, files) presented throughout the publication. However, this collection also contains additional information beyond what is presented, including (1) a VCF file containing all raw SNP calls with dosage data in the original set of 4,625 Sprague Dawley rats, (2) filtered variants in BIM/BED/FAM format for each of the seven Sprague Dawley genetic subgroupings, and (3) summary files for the GWAS results for all 55 metric x training day combinations for all individual subgroups and their meta-analyses. Details on how these files were generated can all be found in the Methods section of the associated publication. This work was funded by the National Institute of Drug Addiction (NIDA; https://www.drugabuse.gov/) through R21 DA036672 (AAP; TER; SBF), P50 DA037844 (AAP; TER; SBF), and F31 DA039638-02 (AFG), as well as training grant T32 GM007197 (AFG) from the National Institute of General Medical Sciences (NIGMS; https://www.nigms.nih.gov/). Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Gileta, Alexander F.; Fitzpatrick, Christopher J.; Chitre, Apurva S.; St. Pierre, Celine L.; Joyce, Elizabeth V.; Maguire, Rachael J.; McLeod, Africa M.; Gonzales, Natalia M.; Williams, April E.; Morrow, Jonathan D.; Robinson, Terry E.; Flagel, Shelly B.; Palmer, Abraham A. (2022). Data from: Genetic characterization of outbred Sprague Dawley rats and utility for genome-wide association studies. UC San Diego Library Digital Collections. https://doi.org/10.6075/J0XS5V8K
Complex trait Quantitative trait locus (QTL) mapping Population structure Psychiatric genetics Rat Pavlovian condition approach Genome-wide association study (GWAS) Genotype by sequencing Meta-analysis Model system Behavioral trait mapping Addiction Sprague Dawley Harlan Charles River Laboratories