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A confocal 4D-stack from a transgenic Drosophila embryo expressing lamin-GFP (green) and injected with rhodamine-conjugated tubulin (red) during surrounding the prometaphase (phase I and II) spindle. Images show a time series of 45 frames from a live embryo, each with six planes through the z axis. Note the indentation of the lamin-B envelope surrounding the spindle by the centrosomes at the opposite ends of the spindle during prometaphase phase I. This image is original data contributing to Fig. 5 "A lamin-B envelope confers robustness to the steady-state prometaphase spindle by stabilizing it to phenotypic variations in the KLP61F to Ncd ratio" from Civelekoglu-Scholey et al.(2010) Prometaphase spindle maintenance by an antagonistic motor-dependent force balance made robust by a disassembling lamin-B envelope, J. Cell Biol. 188(1):49-68. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Civelekoglu-Scholey, Gul; Tao, Li; Brust-Mascher, Ingrid; Wollman, Roy; Scholey, Jonathan M. (2021). CIL:30568, Drosophila melanogaster, early embryonic cell. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0PG1QK5 J Cell Biol. 2010 Jan 11;188(1):49-68. https://doi.org/10.1083/jcb.200908150
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Regulation of mitotic prometaphase Regulation of microtubule-based process Spindle microtubule Kinesin complex Nuclear lamina Early embryonic cell Drosophila melanogaster Cell Image Library Group ID: 8578