Data from: Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks
Contributor
Bimschleger, Hannah George, Anthony Han, Wenyan Holl, Katie King, Christopher P. Lamparelli, Alexander Leger, Brittany S. Martin, Connor Martinez, Angel G. Netzley, Alesa H. Rosenthal, Sara B. St. Pierre, Celine L. Wang, Tengfei Wright, Sarah N. Polesskaya, Oksana Cheng, Riyan Chitre, Apurva S. Gao, Jianjun Gileta, Alexander F. Chen, Hao Flagel, Shelly B. Ishiwari, Keita Meyer, Paul Richards, Jerry Robinson, Terry E. Solberg Woods, Leah C. Ideker, Trey Palmer, Abraham A. Kreisberg, Jason F. Jia, Tongqiu Liu, Sophie
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Description
The data in this object relates to the publication titled “Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks”, authored by Wright, Leger, et al. The majority of the object is dedicated to the phenotypic and genetic data presented in figure two of the manuscript, and for related traits collected for this study. This object also included raw phenotypic measurements for each of the 6,147 rats used in this study. GWAS data was collected and analyzed as described in “Genome-Wide Association Study in 3,173 Outbred Rats Identifies Multiple Loci for Body Weight, Adiposity, and Fasting Glucose” by Chitre et al., 2020 in continuation of this study. This work was supported by the following grants from the National Institutes of Health: NIMH U01 MH115747, NIGMS P41 GM103504, NIDA P50 DA037844, and NIGMS T32 GM008666. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Wright, Sarah N.; Leger, Brittany S.; Rosenthal, Sara B.; Liu, Sophie; Jia, Tongqiu; Chitre, Apurva S.; Polesskaya, Oksana; Holl, Katie; Gao, Jianjun; Cheng, Riyan; Martinez, Angel G.; George, Anthony; Gileta, Alexander F.; Han, Wenyan; Netzley, Alesa H.; King, Christopher P.; Lamparelli, Alexander; Martin, Connor; St. Pierre, Celine L.; Wang, Tengfei; Bimschleger, Hannah; Richards, Jerry; Ishiwari, Keita; Chen, Hao; Flagel, Shelly B.; Meyer, Paul; Robinson, Terry E.; Solberg Woods, Leah C.; Kreisberg, Jason F.; Ideker, Trey; Palmer, Abraham A. (2023). Data from: Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks. In The Center for GWAS in Outbred Rats Database (C-GORD). UC San Diego Library Digital Collections. https://doi.org/10.6075/J0NV9JFT File contents: -- obesity_upublished_data_raw_phenotypes_PalmerLab.csv: raw phenotypes for each of the rats, including the following traits: RFID, BMI without tail, body length with tail, BMI with tail, body length without tail, body weight, sex, and phenotyping center. -- results.bmi_wo_tail.csv: SNP level summary statistics for rat body mass index (BMI) without tail genome-wide association study. -- results.length_wo_tail_cm.csv: SNP level summary statistics for rat body length (bl) without tail genome-wide association study, measured and from nose to the base of the tail (cm). -- results.bmi_w_tail.csv: SNP level summary statistics for rat body mass index (BMI) with tail association study. -- results.length_w_tail_cm.csv: SNP level summary statistics for rat body length (bl) with tail association study, measured and from nose to the end of the tail (cm). -- results.body_weight_g.csv: SNP level summary statistics for rat body weight association study (g). -- Data_Dictionary
Type
dataset
Identifier
ark:/20775/bb83725195
Language
English
Subject
Heterogeneous stock (HS) rats Obesity Complex trait Genetics Body mass index (BMI) Genotype by sequencing (GBS) Genome-wide association study (GWAS) Rat
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