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Publication Abstract: The impact of pH and cations on phase behavior, stability, and surface morphology for dipalmitoyl- phosphatidic acid (DPPA) monolayers was investigated. At pH + > K+ ≈ Mg2+ > Ca2+. Additionally, cation complexation is tied to the pH and protonation state of DPPA, which are the primary factors controlling the monolayer surface behavior. The binding affinity of cations to the headgroup and thus deprotonation capability of the cation, ranked in the order of Ca2+ > Mg2+ > Na+> K+, is found to be well explained by the law of matching water affinities. Nucleation of surface 3D lipid structures is observed from Ca2+, Mg2+, and Na+, but not from K+, consistent with the lowest binding affinity of K+. Unraveling cation and pH effects on DPPA monolayers is useful in further understanding the surface properties of complex systems such as organic-coated marine aerosols where organic films are directly influenced by the pH and ionic composition of the underlying aqueous phase. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp ) Zhang, Ting; Cathcart, Matthew G; Vidalis, Andrew S; Allen, Heather C (2017): Data from: Cation effects on phosphatidic acid monolayers at various pH conditions. In Center for Aerosol Impacts on Chemistry of the Environment (CAICE). UC San Diego Library Digital Collections. https://doi.org/10.6075/J0P26W9D Zhang, T.; Cathcart, M. G.; Vidalis, A. S.; Allen, H. C. Cation effects on phosphatidic acid monolayers at various pH conditions. Chem. Phys. Lipids, 2016, 200, 24–31, https://doi.org/10.1016/j.chemphyslip.2016.06.001 This package contains methods, data, and explanatory readme files to reproduce all figures from the main manuscript and supporting information for “Cation effects on phosphatidic acid monolayers at various pH conditions”.
Phosphatidic acid (PA) Ion Compression isotherms Dipalmitoylphosphatidic acid (DPPA) Brewster angle microscopy (BAM) Protein kinase A (PKA)