Under copyright Constraint(s) on Use: This work is protected by the U.S. Copyright Law (Title 17, U.S.C.). Use of this work beyond that allowed by "fair use" or any license applied to this work requires written permission of the copyright holder(s). Responsibility for obtaining permissions and any use and distribution of this work rests exclusively with the user and not the UC San Diego Library. Inquiries can be made to the UC San Diego Library program having custody of the work. Use: This work is available from the UC San Diego Library. This digital copy of the work is intended to support research, teaching, and private study.
Rights Holder and Contact
UC Regents
Description
A confocal micrograph of an intestinal biopsy from a child infected with shiga toxin-producing E. coli. Shiga toxin is an extremely potent toxin that is produced when the bacterium contains a bacteriophage carrying the toxin gene. It is closely linked with Haemolytic Uraemic Syndrome and acute renal failure in children. After ingestion via contaminated food or water the E. coli bacteria colonize the gut and produce the toxin, which then crosses the gastrointestinal barrier to enter the systemic circulation and reach the kidney and other target organs. In this image, the toxin (green) has crossed into the intestine and is binding to the endothelial cells of the lamina propria (red). Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Schuller, S. (2021). CIL:38952, Homo sapiens, Escherichia coli, endothelial cell. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0TM790G
Type
image
Identifier
ark:/20775/bb87438043
Language
No linguistic content
Subject
Response to bacterium Haemolytic Uraemic Syndrome Detection of bacterium Gram-negative bacterial cell surface binding Lamina propria Endothelial cell Intestine Shiga toxin Homo sapiens Escherichia coli
If you're wondering about permissions and what you can do with this item, a good starting point is the "rights information" on this page. See our terms of use for more tips.
Share your story
Has Calisphere helped you advance your research, complete a project, or find something meaningful? We'd love to hear about it; please send us a message.
