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Rights Holder and Contact
Ricci, Clarisse G.
Description
Caption: A conformational switch of the activation loop in Casein Kinase I controls the circadian clock and the duration of the biological day. Participant category: Postdoc Department: Pharmacology Casein Kinase I phosphorylates key regions of a protein called PERIOD, which forms the core of the biological clock in mammals. The figure superimposes two alternative conformations of Casein Kinase I (cyan and magenta). The clock in the figure highlights the region of the kinase whose conformation controls the duration of the biological day. Mutations that favor the "loop up" conformation (in cyan) lead to shortening of the circadian rhythm and emergence of 'early riser' behavior. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Ricci, Clarisse G. (2021). Early riser or night owl? A flip of a loop can make the difference! In Art of Science. UC San Diego Library Digital Collections. https://doi.org/10.6075/J01J99NX
Type
image
Identifier
ark:/20775/bb9223061p
Language
English
Subject
Art and science PERIOD circadian protein Casein kinase I Art of Science Contest - 2021
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