Under copyright Constraint(s) on Use: This work is protected by the U.S. Copyright Law (Title 17, U.S.C.). Use of this work beyond that allowed by "fair use" or any license applied to this work requires written permission of the copyright holder(s). Responsibility for obtaining permissions and any use and distribution of this work rests exclusively with the user and not the UC San Diego Library. Inquiries can be made to the UC San Diego Library program having custody of the work. Use: This work is available from the UC San Diego Library. This digital copy of the work is intended to support research, teaching, and private study.
Rights Holder and Contact
Clarisse G. Ricci
Description
Caption: A conformational switch of the activation loop in Casein Kinase I controls the circadian clock and the duration of the biological day. Participant category: Postdoc Department: Pharmacology Casein Kinase I phosphorylates key regions of a protein called PERIOD, which forms the core of the biological clock in mammals. The figure superimposes two alternative conformations of Casein Kinase I (cyan and magenta). The clock in the figure highlights the region of the kinase whose conformation controls the duration of the biological day. Mutations that favor the "loop up" conformation (in cyan) lead to shortening of the circadian rhythm and emergence of 'early riser' behavior. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Ricci, Clarisse G. (2021). Early riser or night owl? A flip of a loop can make the difference! In Art of Science. UC San Diego Library Digital Collections. https://doi.org/10.6075/J01J99NX
Type
image
Language
English
Subject
Casein kinase I PERIOD circadian protein Art of Science Contest - 2021
If you're wondering about permissions and what you can do with this item, a good starting point is the "rights information" on this page. See our terms of use for more tips.
Share your story
Has Calisphere helped you advance your research, complete a project, or find something meaningful? We'd love to hear about it; please send us a message.
