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Transmission electron micrograph of transcription of tandemly arranged ribosomal RNA genes. Amphibian oocyte nuclei contain numerous extra-chromosomal nucleoli, each of which contains a tandem array of genes encoding ribosomal RNA. Here, using the methods developed by O.L. Miller Jr. and colleagues, the extrachromosomal nucleoli from a newt oocyte have been dispersed in low salt, and centrifuged through a sucrose cushion containing formaldehyde on to a carbon coated grid and stained for TEM imaging. Active transcription is seen by the tree-like structures in which each branch represents a growing transcript. Untranscribed spacer DNA is seen between each transcript. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Miller, Oscar L.; Fawcett, Don W. (2021). CIL:11043, Notophthalmus viridescens, oocyte. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0TQ60BW
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