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Description
Behavior of a patient-derived human fibroblast line (PD-NC4) containing a mutated chromosome 4 in which the normal centromere is epigenetically silenced and a neo-centromere has formed 25 Mbp down the q arm at a site that lacks centromere repeats. Shown is a z-series of the PD-NC4 chromosome from a metaphase spread stained for CENP-B (red), centromere (ACA, green) and DNA (DAPI blue). See Fig 1D in Bassett et al. 2010. Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors. J Cell Biol 190:177-185. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Bassett, Emily; Wood, Stacey; Salimian, Kevan; Ajith, Sandya; Foltz, Daniel; Black, Ben (2021). CIL:13608, Homo sapiens, fibroblast. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J00000T6
Type
image
Identifier
ark:/20775/bb60817599
Language
No linguistic content
Subject
PD-NC4 Mitosis Chromosome, centromeric region Fibroblast Nuclear chromosome Homo sapiens Cell Image Library Group ID: 8693
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