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Description
Behavior of a patient-derived human fibroblast line (PD-NC4) containing a mutated chromosome 4 in which the normal centromere is epigenetically silenced and a neo-centromere has formed 25 Mbp down the q arm at a site that lacks centromere repeats. Shown is a z-series of an example of the PD-NC4 chromosome (upper, center) failing to align when the normal chromosomes have corrected syntelic attachments after monastrol withdrawal and are nearly aligned on the metaphase plate. Stained for DNA with DAPI (blue), CENP-C (green), and anti-centromere antibodies (ACA, red). See Fig 3C in Bassett et al. 2010. Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors. J Cell Biol 190:177-185. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Bassett, Emily; Wood, Stacey; Salimian, Kevan; Ajith, Sandya; Foltz, Daniel; Black, Ben (2021). CIL:13606, Homo sapiens, fibroblast. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0WD3Z8Z
Type
image
Identifier
ark:/20775/bb6866747v
Language
No linguistic content
Subject
PD-NC4 Mitosis Chromosome, centromeric region Nuclear chromosome Fibroblast Homo sapiens Cell Image Library Group ID: 8693
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