Under copyright Constraint(s) on Use: This work is protected by the U.S. Copyright Law (Title 17, U.S.C.). Use of this work beyond that allowed by "fair use" or any license applied to this work requires written permission of the copyright holder(s). Responsibility for obtaining permissions and any use and distribution of this work rests exclusively with the user and not the UC San Diego Library. Inquiries can be made to the UC San Diego Library program having custody of the work. Use: This work is available from the UC San Diego Library. This digital copy of the work is intended to support research, teaching, and private study.
Rights Holder and Contact
UC Regents
Description
A confocal Z-stack of neurons in postnatal hippocampus, expressing a GFP-tagged knockdown construct for the microRNA miR-137 (green, sh-miR-137), a marker of neuronal differentiation, çand BrdU (red) to localize total cells and newly-generated cells respectively. miR-137 regulates a core transcription factor in stem cell renewal. Data from these experiments suggest that high levels of miR-137 promotes neuronal stem cell proliferation, but repressed neuronal differentiation. This image is original data from Fig. 5 of Szulwach et al.(2010) Cross talk between microRNA and epigenetic regulation in adult neurogenesis, J. Cell Biol. Vol. 189:127–141. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Szulwach, Keith E.; Li, Xuekun; Smrt, Richard D.; Li, Yujing; Luo, Yuping; Lin, Li; Santistevan, Nicholas J.; Li, Wendi; Zhao, Xinyu; Jin, Peng (2021). CIL:13524, Mus musculus, neuronal stem cell. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J02F7MB4
Type
image
Identifier
ark:/20775/bb7071358x
Language
No linguistic content
Subject
Regulation of neurogenesis Regulation of neuron differentiation Nucleus Neuronal stem cell Mus musculus Cell Image Library Group ID: 8575
If you're wondering about permissions and what you can do with this item, a good starting point is the "rights information" on this page. See our terms of use for more tips.
Share your story
Has Calisphere helped you advance your research, complete a project, or find something meaningful? We'd love to hear about it; please send us a message.
