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Description
A confocal Z-stack of neurons in postnatal hippocampus, expressing a GFP-tagged knockdown construct for the microRNA miR-137 (green, sh-miR-137) and immunostained to localize doublecortin (red), a marker of neuronal differentiation, and labeled with Dapi (blue), to determine the function of this microRNA in vivo. miR-137 regulates a core transcription factor in stem cell renewal, and data from these experiments suggest that high levels of miR-137promotes neuronal stem cell proliferation, but repressed neuronal differentiation. This image is original data from Fig. 5 of Szulwach et al.(2010) Cross talk between microRNA and epigenetic regulation in adult neurogenesis, J. Cell Biol. Vol. 189:127–141. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Szulwach, Keith E.; Li, Xuekun; Smrt, Richard D.; Li, Yujing; Luo, Yuping; Lin, Li; Santistevan, Nicholas J.; Li, Wendi; Zhao, Xinyu; Jin, Peng (2021). CIL:13523, Mus musculus, neuronal stem cell. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0JQ0ZVF
Type
image
Identifier
ark:/20775/bb9835915n
Language
No linguistic content
Subject
Regulation of neurogenesis Regulation of neuron differentiation Nucleus Neuronal stem cell Mus musculus Cell Image Library Group ID: 8575
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