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Junctional complex between two cells in the epithelium of the rat intestinal mucosa. The tight junction (also known as zonula occludens, ZO) located nearest to the lumen extends from arrow 1 to arrow 2. The elimination of the intercellular gap (approx 90 angstroms) is clearly visible, but the fusion line of the two apposed membranes cannot be clearly distinguished at this magnification. The adherens junction (also known as zonula adherens, ZA) extends from arrow 3 to arrow 4. A relatively wide intercellular space (approx 200 angstroms) is maintained throughout this junction. Extensive actin filament networks are seen along both sides of the junction (Actin) which are continuous with the terminal web (TW) into which the filamentous rootlets of the mircovilli penetrate. Dense material (DM) can be seen along parts of both sides of the junction. The limits of a desmosome are marked by arrows 5 and 6. Desmosomes are characterized by a wide intracellular space (approx 240 angstroms) bisected by an intermediate line (id). Bundles of intermediate filaments (if, diameter approx 80 angstroms) converge into a dense plaque (DP) on each side of the desmosome. The trilaminar structure of the cell membrane (CM) is clearly seen along the microvilli (MV), between the ZA and the desmosome and within the desmosome. First description of 1) tight junctions and 2) the junctional complexes between epithelial cells, consisting of tight junction, adherens junction and a desmosome. Identical unlabeled image available as CIL# 7620. Image published as Figure 1 in Farquhar and Palade, 1963. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Farquhar, Marilyn G.; Palade, George E. (2021). CIL:7621, Rattus rattus, epithelial cell, intestinal epithelial cell. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0W37V10
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