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Description
Mouse myoblast cells were transfected with GFP-PCNA (proliferating cell nuclear antigen) as a marker for replication factories, pulsed with BrdU, fixed, and immunostained with anti-BrdU. The image shows t different typical S-phase patterns displaying GFP-PCNA (left, green), BrdU (red, center) and the merged images (right). The dominant yellow coloration in the merges shows the strong localization of PCNA at replication foci. Other images in this group show the co-localization of enzymes associated with DNA replication at foci and the dynamic changes in the GFP-PCNA signal in individual foci over time. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Leomhardt, Heinrich; Rahn, Hans-Peter; Weinziert, Peter; Sporbert, Anje; Cremer, Thomas; Zink, Daniele; Cordoso, M. Cristina (2021). CIL:39254, Mus musculus, myoblast. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J02V2DR8
Type
image
Identifier
ark:/20775/bb3761097s
Language
No linguistic content
Subject
C2C12 DNA replication DNA metabolic process Nuclear chromatin Nuclear DNA Myoblast Mus musculus Cell Image Library Group ID: 10204
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