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The C2C12 cell line, a mouse myoblast line, was used here to study the regulatory factors in myogenic differentiation. After cultured in differentiation medium for 3 days, these cells differentiated into myotubes (Green) containing multiple nuclei (Blue). The myoblasts in this image were treated with 300ng/ml insulin-like growth factor II (IGF-II) and 50nM rapamycin (Rap) during differentiation. In the presence of both IGF-II and rapamycin, C2C12 cells differentiated into myotubes but arrested at a small myotube size with fewer myonuclei than mature myotubes. This image is one of different treatments in Figure 9A from JCB 189: 1157-1169, 2010. See also CIL: 13589, 13591. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Sun, Yuting; Ge, Yejing; Drnevich, Jenny; Zhao, Yong; Band, Mark; Chen, Jie (2021). CIL:13590, Mus musculus, myoblast. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0BP01J1 JCB 189: 1157-1169, 2010 https://www.ncbi.nlm.nih.gov/pubmed/?term=20566686
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