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Description
Expression of transmembrane domain deleted-PINK1-YFP (green) is stabilized in the mitochondira, but does not induce mitochondrial translocation of mCherry-Parkin (red) in PINK1 knock-out mouse embryonic fibroblasts (PINK1 KO MEFs). Transfected PINK1 KO MEFs were treated with DMSO for 3 hrs. Live cell imaging was performed on an LSM510 Meta (Carl Zeiss, Inc) with a 63x 1.4 NA oil differential interference contrast Plan Apo objective. Image contrast and brightness were adjusted in the LSM image browser (Zeiss). This image corresponds to Supplemental Figure S1c, top right row of J Cell Biol, 191: 933-942, 2010. Images in Supplemental Figure S1c include CIL#s 13725, 13726, 13727, 13728. Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp) Jin, Seok Min; Lazarou, Michael; Wang, Chunxin; Kane, Lesley A.; Narendra, Derek P.; Youle, Richard J. (2021). CIL:13725, Mus musculus, fibroblast. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0028Q70
Type
image
Identifier
ark:/20775/bb9836063d
Language
No linguistic content
Subject
Protein serine/threonine kinase activity Zinc ion binding C3HC4-type RING finger domain binding ATP binding Calcium-dependent protein kinase activity Protein ubiquitination involved in ubiquitin-dependent protein catabolic process Response to stress Protein K48-linked ubiquitination Ubiquitin-protein ligase activity Protein K63-linked ubiquitination Protein phosphorylation Protein binding Intracellular protein kinase cascade Mitochondrion degradation Ubiquitin protein ligase binding Magnesium ion binding Mitochondrion Nucleus Mitochondrial outer membrane Cytosol Fibroblast Mitochondrial inner membrane Mus musculus Cell Image Library Group ID: 7051
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